The global production of processing tomatoes is concentrated in a small number of regions where climate change could have a notable impact on the future supply. Process-based tomato models project that the production in the main producing countries (the United States, Italy and China, representing 65% of global production) will decrease 6% by 2050 compared with the baseline period of 1980–2009. The predicted reduction in processing tomato production is due to a projected increase in air temperature. Under an ensemble of projected climate scenarios, California and Italy might not be able to sustain current levels of processing tomato production due to water resource constraints. Cooler producing regions, such as China and the northern parts of California, stand to improve their competitive advantage. The projected environmental changes indicate that the main growing regions of processing tomatoes might change in the coming decades.