Trisubstituted macrocyclic alkenes are prominent moieties in natural products, and although ring-closing metathesis reactions can be used to access such targets, the yields are typically suboptimal and the stereochemical outcome is unpredictable. Now, a methodology has been developed that tackles both of these challenges.

中文翻译：

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三取代的胜利

三取代的大环烯烃是天然产物中的重要组成部分，虽然闭环复分解反应可用于接近这些目标，但产率通常不是最理想的，立体化学结果是不可预测的。现在，已经开发出一种方法来解决这两个挑战。