Existing technologies can map the intricate spatial distribution of biomolecules and cell types within tissues, but not in specimens that remain alive and intact. This study introduces scission-accelerated fluorophore exchange (SAFE) bioorthogonal imaging tools that enable living cells and tissues to be deeply and serially profiled, revealing their biological dynamics across both space and time.

中文翻译：

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多种颜色的活细胞和组织可视化

现有技术可以绘制出组织内生物分子和细胞类型的复杂空间分布，但无法绘制出仍然存活且完好无损的标本。本研究介绍了断裂加速荧光团交换 (SAFE) 生物正交成像工具，使活细胞和组织能够深入连续地进行分析，揭示它们在空间和时间上的生物动力学。