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Exploring Z-Tyr-Phe-OH-based hydrogels loaded with curcumin for the development of dressings for wound healing
Journal of Drug Delivery Science and Technology ( IF 5 ) Pub Date : 2022-06-06 , DOI: 10.1016/j.jddst.2022.103484
Cátia Alves , Artur Ribeiro , Eugénia Pinto , Jorge Santos , Graça Soares

The poor mechanical performance and difficulty of using wound dressings without discomfort to the patient motivated the development of textile composites, incorporating peptide hydrogels in textile matrices. Thus, 70% viscose and 30% polyester non-woven and 100% cotton bandages were functionalized by impregnation with a hydrogel resulting from physical crosslinking of Z-Tyr-Phe-OH dipeptide. The healing properties of these structures resulted from the incorporation of curcumin into the polymer. The textile composites were characterized by Scanning Electron Microscopy (SEM), Fourier Transform Infrared Spectroscopy (FTIR), Differential Scanning Calorimetry (DSC), Thermogravimetric Analysis (TGA), and colour strength (K/S) with differences being observed after functionalization with the hydrogel (higher surface smoothness and thermal stability). The breathability and moisture management properties of the new composites were similar to those of commercial dressings, and the pH value of the aqueous extract resembled skin. The swelling of the composites increased significantly due to the contribution of the hydrogel. Furthermore, the textile composites released the curcumin for a long time with an initial burst release in the first 2 h and showed good antibacterial and antifungal properties, without displaying significant cytotoxicity on fibroblasts. Overall, the composites here were developed to meet the main requirements of dressings for the management and treatment of skin wounds.



中文翻译:

探索基于 Z-Tyr-Phe-OH 的载有姜黄素的水凝胶,用于开发用于伤口愈合的敷料

较差的机械性能和使用伤口敷料而不会给患者带来不适的困难推动了纺织复合材料的发展,将肽水凝胶结合到纺织基质中。因此,70% 粘胶纤维和 30% 聚酯无纺布和 100% 棉绷带通过浸渍由 Z-Tyr-Phe-OH 二肽物理交联产生的水凝胶进行功能化。这些结构的愈合特性是由姜黄素掺入聚合物中引起的。通过扫描电子显微镜 (SEM)、傅里叶对纺织品复合材料进行表征变换红外光谱 (FTIR)、差示扫描量热法 (DSC)、热重分析 (TGA) 和颜色强度 (K/S),在水凝胶功能化后观察到差异(更高的表面光滑度和热稳定性)。新复合材料的透气性和水分管理特性与商业敷料相似,水提取物的 pH 值类似于皮肤。由于水凝胶的贡献,复合材料的溶胀显着增加。此外,纺织品复合材料长时间释放姜黄素,在前 2 小时内首次爆发释放,并显示出良好的抗菌和抗真菌特性,对成纤维细胞没有显着的细胞毒性。全面的,

更新日期:2022-06-08
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