Immune response leading to increased systemic inflammation is one of the mechanisms linking periodontitis to chronic inflammatory diseases. The aim of this study was to compare the expression of toll-like receptors 2 and 4 in monocytes and neutrophils (TLR2M, TLR2N, TLR4M, and TLR4N) and its endogenous ligands (cellular fibronectin [cFN] and heat shock protein 60 [HSP60]) in patients with and without periodontitis. Additionally, the relationship between cFN and HSP60 expression with innate immunity activation and systemic inflammatory response (interleukin 6 [IL-6]) was also evaluated.

中文翻译：

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牙周炎与先天免疫激活和炎症的外周标志物之间的关联

导致全身炎症增加的免疫反应是将牙周炎与慢性炎症性疾病联系起来的机制之一。本研究的目的是比较单核细胞和中性粒细胞（TLR2M、TLR2N、TLR4M 和 TLR4N）及其内源性配体（细胞纤连蛋白 [cFN] 和热休克蛋白 60 [HSP60]）中 toll 样受体 2 和 4 的表达) 患有和不患有牙周炎的患者。此外，还评估了 cFN 和 HSP60 表达与先天免疫激活和全身炎症反应（白细胞介素 6 [IL-6]）之间的关系。