Objective

To investigate preeclampsia risk of pregnant women living in coastal areas regularly impacted by massive sargassum strandings.

Design

Retrospective cohort study

Settings and population

Pregnant women (n = 3020), seen at the University Hospital of Martinique, were included between 25/01/2016 and 31/07/2020.

Methods

Patient records were retrospectively reviewed. Distance from coastline sargassum stranding sites was characterized as follows: < 500 m, 500 m-2 km, > 2 km.

Main outcome measures

Primary endpoint was occurrence of preeclampsia. Secondary endpoint was time to preeclampsia defined as the number of weeks free of preeclampsia between the 20th and 37th week of amenorrhea.

Results

Time to preeclampsia onset was significantly shorter in women living in the ≤ 2 km range (mean survival time 32 ± 1 amenorrhea weeks) compared to those beyond 2 km (mean survival time 35 ± 1 amenorrhea weeks, p = 0.037).

Conclusion

Along with traditional risk factors, environmental exposure to sargassum strandings might potentially trigger early onset of preeclampsia.

中文翻译：

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法属加勒比海马提尼克岛受马尾藻搁浅影响的沿海地区妇女患先兆子痫的风险

 客观的

调查生活在经常受到大规模马尾藻搁浅影响的沿海地区的孕妇的先兆子痫风险。

 设计

回顾性队列研究

 环境和人口

2016 年 1 月 25 日至 2020 年 7 月 31 日期间在马提尼克大学医院就诊的孕妇 (n = 3020) 被纳入研究。

 方法

对患者记录进行了回顾性审查。距海岸线马尾藻搁浅点的距离特征如下：< 500 m、500 m-2 km、> 2 km。

 主要观察指标

主要终点是先兆子痫的发生。次要终点是发生先兆子痫的时间，定义为闭经第 20 周和第 37 周之间没有先兆子痫的周数。

 结果

与生活距离超过 2 公里的女性（平均生存时间 35 ± 1 闭经周，p = 0.037）相比，生活在 ≤ 2 公里范围内的女性（平均生存时间 32 ± 1 闭经周）的先兆子痫发病时间显着缩短。

 结论

除了传统的风险因素外，暴露于马尾藻搁浅的环境可能会引发先兆子痫的早期发作。