Early Coronary Atherosclerosis in Women With Previous Preeclampsia,Journal of the American College of Cardiology

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Early Coronary Atherosclerosis in Women With Previous Preeclampsia
Journal of the American College of Cardiology ( IF 21.7 ) Pub Date : 2022-06-06 , DOI: 10.1016/j.jacc.2022.03.381
Maria G Hauge ₁ , Peter Damm ₁ , Klaus F Kofoed ₂ , Anne S Ersbøll ₃ , Marianne Johansen ₃ , Per E Sigvardsen ₄ , Mathias B Møller ₄ , Andreas Fuchs ₄ , Jørgen T Kühl ₄ , Børge G Nordestgaard ₅ , Lars V Køber ₆ , Finn Gustafsson ₆ , Jesper J Linde ₄

Affiliation

Background

Women with previous preeclampsia have an increased risk of coronary artery disease later in life.

Objectives

This study aimed to determine the prevalence of coronary atherosclerosis in younger women with previous preeclampsia in comparison with women from the general population.

Methods

Women aged 40-55 years with previous preeclampsia were matched 1:1 on age and parity with women from the general population. Participants completed an extensive questionnaire, a clinical examination, and a coronary computed tomography angiography (CTA). The main study outcome was the prevalence of any coronary atherosclerosis on coronary CTA or a calcium score >0 in case of a nondiagnostic coronary CTA.

Results

A total of 1,417 women, with a mean age of 47 years, were included (708 women with previous preeclampsia and 709 control subjects from the general population). Women with previous preeclampsia were more likely to have hypertension (284 [40.1%] vs 162 [22.8%]; P < 0.001), dyslipidemia (338 [47.7%] vs 296 [41.7%]; P = 0.023), diabetes mellitus (24 [3.4%] vs 8 [1.1%]; P = 0.004), and high body mass index (27.3 ± 5.7 kg/m² vs 25.0 ± 4.2 kg/m²; P < 0.001). Cardiac computed tomography was performed in all women. The prevalence of any coronary atherosclerosis was higher in the preeclampsia group (193 [27.4%] vs 141 [20.0%]; P = 0.001) with an OR: 1.41 (95% CI: 1.08-1.85; P = 0.012) after adjustment for age, dyslipidemia, diabetes mellitus, smoking, body mass index, menopause, and parity.

Conclusions

Younger women with previous preeclampsia had a slightly higher prevalence of coronary atherosclerosis compared with age- and parity-matched women from the general population. Preeclampsia remained an independent risk factor after adjustment for traditional cardiovascular risk factors. (The CoPenHagen PREeClampsia and cardIOvascUlar diSease study [CPH-PRECIOUS]; NCT03949829)

中文翻译：

子痫前期妇女的早期冠状动脉粥样硬化

背景

患有先兆子痫的女性在以后的生活中患冠状动脉疾病的风险增加。

目标

本研究旨在确定患有先兆子痫的年轻女性与普通人群女性相比冠状动脉粥样硬化的患病率。

方法

患有先兆子痫的 40-55 岁女性在年龄和性别上与普通人群中的女性进行 1:1 匹配。参与者完成了广泛的问卷调查、临床检查和冠状动脉计算机断层扫描血管造影 (CTA)。主要研究结果是冠状动脉 CTA 上任何冠状动脉粥样硬化的患病率或在非诊断性冠状动脉 CTA 的情况下钙评分 > 0。

结果

共纳入 1,417 名女性，平均年龄为 47 岁（708 名患有先兆子痫的女性和 709 名来自普通人群的对照受试者）。患有先兆子痫的女性更可能患有高血压（284 [40.1%] vs 162 [22.8%]；P < 0.001）、血脂异常（338 [47.7%] vs 296 [41.7%]；P = 0.023）、糖尿病（ 24 [3.4%] vs 8 [1.1%]；P = 0.004)，以及高体重指数 (27.3 ± 5.7 kg/m ² vs 25.0 ± 4.2 kg/m ²；P < 0.001)。所有女性均进行了心脏计算机断层扫描。先兆子痫组任何冠状动脉粥样硬化的患病率较高（193 [27.4%] vs 141 [20.0%]；P = 0.001），在调整年龄、血脂异常、糖尿病、吸烟、体重指数、更年期和产次后， OR：1.41（95% CI：1.08-1.85；P = 0.012）。