The aim of this study was to conduct a systematic review and meta-analysis of cohort studies that have examined the association between frailty and all-cause mortality in patients with HIV infection. We searched Embase, Medline through the Ovid interface, PubMed, Cochrane Library, and Web of Science to identify potential studies. Cohort studies of death outcomes in HIV patients under debilitating conditions were included and other ineligible or inadequate data were excluded. Data related to all-cause mortality in patients with HIV were extracted. The quality of the included studies was assessed using the Newcastle–Ottawa Scale for cohort studies. Hazard ratios (HRs) and their 95% confidence intervals (CIs) were pooled to estimate the association between frailty and all-cause mortality using Stata, version 12.0. We identified 845 unduplicated citations. Of these, six cohort studies were eligible for inclusion in the review after applying our inclusion and exclusion criteria. Pooled results demonstrated that patients with HIV experiencing frailty were at an increased risk of all-cause mortality (pooled HR = 2.69, 95% CI = 1.83–3.97, p < .001) compared with those without frailty. Frailty was significantly associated with an increased risk of all-cause mortality among patients with HIV, indicating that frailty is an important predictor of adverse clinical outcomes. Therefore, more attention should be paid to screen patients with HIV for frailty and adopt appropriate interventions and personalized treatment plans to prevent the occurrence of adverse events. However, these results need to be validated in further prospective cohort studies in ethnically or geographically diverse populations.

中文翻译：

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虚弱对 HIV 感染患者全因死亡率的影响：系统评价和荟萃分析

本研究的目的是对队列研究进行系统回顾和荟萃分析，这些队列研究检查了 HIV 感染患者的虚弱和全因死亡率之间的关系。我们通过 Ovid 界面、PubMed、Cochrane 图书馆和 Web of Science 搜索了 Embase、Medline 以确定潜在的研究。HIV 患者在虚弱条件下的死亡结果队列研究被纳入，其他不合格或不充分的数据被排除在外。提取了与 HIV 患者全因死亡率相关的数据。使用纽卡斯尔-渥太华队列研究量表评估纳入研究的质量。使用 Stata 12.0 版汇总风险比 (HR) 及其 95% 置信区间 (CI) 以估计虚弱与全因死亡率之间的关联。我们确定了 845 次未重复的引用。其中，六项队列研究在应用我们的纳入和排除标准后符合纳入审查的条件。汇总结果表明，患有虚弱的 HIV 患者的全因死亡率风险增加（汇总 HR = 2.69，95% CI = 1.83–3.97，p  < .001) 与没有虚弱的人相比。虚弱与 HIV 患者全因死亡率风险增加显着相关，表明虚弱是不良临床结果的重要预测指标。因此，应更加重视对HIV感染者进行衰弱筛查，并采取适当的干预措施和个性化的治疗方案，以预防不良事件的发生。然而，这些结果需要在种族或地理上不同人群的进一步前瞻性队列研究中得到验证。