The immune system is highly time-of-day dependent. Pioneering studies in the 1960s were the first to identify immune responses to be under a circadian control. Only in the last decade, however, have the molecular factors governing circadian immune rhythms been identified. These studies have revealed a highly complex picture of the interconnectivity of rhythmicity within immune cells with that of their environment. Here, we provide a global overview of the circadian immune system, focusing on recent advances in the rapidly expanding field of circadian immunology.

中文翻译：

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昼夜免疫系统

免疫系统高度依赖时间。1960 年代的开创性研究首次确定免疫反应受昼夜节律控制。然而，仅在过去十年中，才确定了控制昼夜免疫节律的分子因素。这些研究揭示了免疫细胞内节律性与其环境节律性相互联系的高度复杂的图景。在这里，我们提供了昼夜免疫系统的全球概述，重点介绍了快速发展的昼夜免疫学领域的最新进展。