Chiral ionic liquids (CILs) have attracted more and more attention due to their superior performance as chiral additives in capillary electrophoresis. In this work, based on the cyclodextrin (CD) derivatives and three new amino acid CILs (trifluoroacetate-L-Hydroxyproline, nitric acid-L-Hydroxyproline and trifluoroacetate-L-threonine), the new synergistic systems were established for chiral drug separation. In contrast to the traditional single glucosyl-β-CD (Glu-β-CD) separation system, the CIL/Glu-β-CD synergistic systems achieved improved resolution of three model drug racemates. Some experimental variables, such as CIL concentration, Glu-β-CD concentration, buffer pH, applied voltage, and the type and proportion of organic modifier, were optimized in the trifluoroacetate-L-Hydroxyproline/Glu-β-CD synergistic system. In addition, the recognition process in the synergistic system was studied through the molecular modeling method.

中文翻译：

---

毛细管电泳中三种新型氨基酸手性离子液体作为添加剂的环糊精基协同对映分离体系的建立及分子模型研究

手性离子液体 (CILs) 因其在毛细管电泳中作为手性添加剂的卓越性能而受到越来越多的关注。在这项工作中，基于环糊精（CD）衍生物和三种新的氨基酸CIL（三氟乙酸-L-羟脯氨酸，硝酸-L-羟脯氨酸和三氟乙酸-L-苏氨酸），建立了用于手性药物分离的新协同系统。与传统的单糖基-β-CD (Glu-β-CD) 分离系统相比，CIL/Glu-β-CD 协同系统提高了三种模型药物外消旋体的分离度。在三氟乙酸-L-羟脯氨酸/Glu-β-CD 协同体系中优化了 CIL 浓度、Glu-β-CD 浓度、缓冲液 pH 值、施加电压以及有机改性剂的类型和比例等实验变量。此外，