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Catalytic Asymmetric Synthesis of 2,6-Disubstituted Cuneanes through Enantioselective Constitutional Isomerization of 1,4-Disubstituted Cubanes
European Journal of Organic Chemistry ( IF 2.5 ) Pub Date : 2022-05-31 , DOI: 10.1002/ejoc.202200567 Hiyori Takebe 1 , Seijiro Matsubara 2
European Journal of Organic Chemistry ( IF 2.5 ) Pub Date : 2022-05-31 , DOI: 10.1002/ejoc.202200567 Hiyori Takebe 1 , Seijiro Matsubara 2
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2,6-Substituted cuneanes were obtained by metal-catalyzed isomerization of 1,4-disubstituted cubanes and are stable cage-like hexahedral compounds with C2v symmetry. In this process, the chiral cage-like hexahedral hydrocarbon in one step. The asymmetric induction was performed using chiral P−C−P pincer Pd catalyst. The obtained cuneane will be a novel chiral scaffold.
中文翻译：
通过1,4-二取代古巴烷的对映选择性结构异构化催化不对称合成2,6-二取代立方烷
2,6-取代的立方烷是通过金属催化的1,4-二取代立方烷异构化得到的，是具有C 2 v对称性的稳定的笼状六面体化合物。在这一过程中，手性笼状六面体烃一步到位。使用手性 P-C-P 钳 Pd 催化剂进行不对称诱导。所获得的 cuneane 将是一种新型的手性支架。
更新日期：2022-05-31
中文翻译：
通过1,4-二取代古巴烷的对映选择性结构异构化催化不对称合成2,6-二取代立方烷
2,6-取代的立方烷是通过金属催化的1,4-二取代立方烷异构化得到的，是具有C 2 v对称性的稳定的笼状六面体化合物。在这一过程中，手性笼状六面体烃一步到位。使用手性 P-C-P 钳 Pd 催化剂进行不对称诱导。所获得的 cuneane 将是一种新型的手性支架。
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