Advances in early diagnosis of cervical cancer based on biosensors,Biotechnology and Bioengineering

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Advances in early diagnosis of cervical cancer based on biosensors
Biotechnology and Bioengineering ( IF 3.5 ) Pub Date : 2022-06-03 , DOI: 10.1002/bit.28149
Hadi Esmaeili Gouvarchin Ghaleh ₁ , Alireza Shahriary ₂ , Morteza Izadi ₃ , Mahdieh Farzanehpour ₁

Affiliation

Human papillomavirus (HPV) is a causative agent of cervical cancer among women worldwide. Serological and molecular tests are commonly used to detect and identify HPV, but all the detection methods for HPV have some limitations. Nowadays, considerable advancements in nanosensors have enabled monitoring of hybridization procedures dynamically for HPV detection. Biosensors, as effective, quick, economical, and highly sensitive tools, can be used in the diagnosis of HPV as an alternative technique instead of other detection methods. Biosensor detection methods of HPV in use from 2000 to 2021 were investigated using several databases such as Google Scholar, Scopus, PubMed, and the Scientific Information Database. Furthermore, a manual search of the references of the retrieved articles was performed. On analyzing the most recently developed biosensors for HPV identification, we observed that three biosensor systems, electrochemical, optical, and piezoelectric systems, are the main transducers used in the development of HPV biosensors. The aim of this review is to examine recent research on biosensors for the detection of HPV and perform a comparison with other diagnostic methods. Considering the importance of rapid HPV detection in the control of infection and development of public health measures, improvement of biosensors as an economical and quick method can be very useful in the diagnosis of HPV.

中文翻译：

基于生物传感器的宫颈癌早期诊断研究进展

人乳头瘤病毒 (HPV) 是全世界女性宫颈癌的病原体。血清学和分子学检测通常用于检测和鉴定HPV，但所有的HPV检测方法都存在一定的局限性。如今，纳米传感器的相当大的进步使得能够动态监测杂交程序以检测 HPV。生物传感器作为一种有效、快速、经济和高灵敏度的工具，可作为替代其他检测方法的替代技术用于 HPV 诊断。使用谷歌学术、Scopus、PubMed 和科学信息数据库等多个数据库研究了 2000 年至 2021 年使用的 HPV 的生物传感器检测方法。此外，对检索到的文章的参考文献进行了手动搜索。在分析最近开发的用于 HPV 识别的生物传感器时，我们观察到三种生物传感器系统，电化学、光学和压电系统，是用于开发 HPV 生物传感器的主要传感器。本综述的目的是检查最近对用于检测 HPV 的生物传感器的研究，并与其他诊断方法进行比较。考虑到快速 HPV 检测在控制感染和制定公共卫生措施中的重要性，改进生物传感器作为一种经济、快速的方法对于 HPV 的诊断非常有用。本综述的目的是检查最近对用于检测 HPV 的生物传感器的研究，并与其他诊断方法进行比较。考虑到快速 HPV 检测在控制感染和制定公共卫生措施中的重要性，改进生物传感器作为一种经济、快速的方法对于 HPV 的诊断非常有用。本综述的目的是检查最近对用于检测 HPV 的生物传感器的研究，并与其他诊断方法进行比较。考虑到快速 HPV 检测在控制感染和制定公共卫生措施中的重要性，改进生物传感器作为一种经济、快速的方法对于 HPV 的诊断非常有用。

更新日期：2022-06-03

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