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Cytokine aerobics: Oxidation controls cytokine dynamics and function
Structure ( IF 4.4 ) Pub Date : 2022-06-02 , DOI: 10.1016/j.str.2022.05.005
Markus Brandhofer 1 , Jürgen Bernhagen 2
Affiliation  

In this issue of Structure, Skeens et al. provide insights into the structure and dynamics of an oxidized form of the atypical cytokine macrophage migration-inhibitory factor (MIF). The study unveils a surprising conformational susceptibility of MIF to ambient redox alterations and identifies redox-sensitive residues and latent allostery sites with functional relevance.



中文翻译:

细胞因子有氧运动:氧化控制细胞因子动力学和功能

在本期结构中,Skeens 等人。提供对非典型细胞因子巨噬细胞迁移抑制因子 (MIF) 氧化形式的结构和动力学的见解。该研究揭示了 MIF 对环境氧化还原变化的惊人构象敏感性,并确定了具有功能相关性的氧化还原敏感残基和潜在变构位点。

更新日期:2022-06-04
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