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Relationship between lifespan and somatic mutation in D. melanogaster after treatment with chlorophyllin
Environmental Toxicology and Pharmacology ( IF 4.2 ) Pub Date : 2022-05-30 , DOI: 10.1016/j.etap.2022.103891
Martha Patricia Cruces 1 , Elena González 1 , Emilio Pimentel 1 , Elizabeth Jiménez 1 , Petra Sánchez 2
Affiliation  

Sodium copper chlorophyllin (SCC) has a genetic damage inhibitory capacity due to its antioxidant action. For this reason, it was considered to investigate its role in the life span of Drosophila melanogaster and its relationship with the frequency of somatic mutation induced by gamma rays. Results indicated that SCC alone prolonged the lifespan only in females, but in combination with 20 Gy of gamma rays, the aging delay in both sexes was significant. In addition to confirming that the porphyrin reduces the frequency of mutation, the individuals with the highest mutation load are the individuals who die more quickly, and once they are eliminated, the survivor individuals treated with 20 Gy or with SCC + 20 Gy, died at the same rate. The results together indicate that SCC not only inhibits induced genetic damage, but it also has beneficial effects that probably cause an aging delay of the treated population that need to be investigated.



中文翻译:

叶绿素处理后黑腹果蝇寿命与体细胞突变的关系

叶绿素铜钠 (SCC) 因其抗氧化作用而具有抑制遗传损伤的能力。因此,考虑研究其在黑腹果蝇寿命中的作用及其与伽马射线诱发的体细胞突变频率的关系。结果表明,仅 SCC 可延长女性的寿命,但与 20 Gy 的伽马射线相结合,两性的衰老延迟均显着。除了证实卟啉降低了突变频率外,突变负荷最高的个体是死亡更快的个体,一旦被淘汰,20 Gy 或 SCC + 20 Gy 治疗的幸存者个体死亡时间为相同的比率。结果共同表明,SCC 不仅抑制诱导的遗传损伤,而且还具有可能导致需要研究的治疗人群衰老延迟的有益作用。

更新日期:2022-06-04
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