Background: 

Previous research indicated that diabetes during pregnancy results in a more permeable placenta. Based on this data, we hypothesized that women with maternal diabetes were more likely to have infants who developed neonatal abstinence syndrome (NAS).

Purpose: 

The purpose of the study was to examine the association between maternal diabetes and NAS in a cohort of women reporting substance use during pregnancy.

Methods: 

This study used data from a population-based cohort of all newborns born in 2017 and 2018 (N = 36,974) in the state of West Virginia and restricted the analysis to those infants with intrauterine substance exposure (14%, n = 5188). Multiple logistic regression was performed to analyze the adjusted relationship between maternal diabetes and NAS while controlling for maternal and infant covariates.

Results: 

Just over 28% of women with diabetes had an infant who developed NAS, whereas 34.8% of women without diabetes had an infant who developed NAS. The adjusted odds ratio of infants developing NAS born to women with diabetes was 0.70 (95% confidence interval: 0.51, 0.94) compared with those born to mothers without diabetes after controlling for covariates. Contrary to our hypothesis, the study suggests that maternal diabetes during pregnancy is associated with a decreased risk of an infant developing NAS.

Implications for Practice: 

Future research generating from this hypothesis may lead to potential implications for practice for infants born to mothers with substance use during pregnancy and diabetes.

Implications for Research: 

More research should be conducted to investigate the relationship between glucose metabolism and NAS.

中文翻译：

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阐明产妇糖尿病与新生儿禁欲综合征之间的关系：2017-2018 年农村阿巴拉契亚项目 WATCH 研究

背景： 

先前的研究表明，怀孕期间的糖尿病会导致胎盘更具渗透性。基于这些数据，我们假设患有母体糖尿病的女性更可能生下患有新生儿戒断综合征 (NAS) 的婴儿。

目的： 

该研究的目的是在一组报告怀孕期间使用药物的妇女中检查母亲糖尿病与 NAS 之间的关系。

方法： 

本研究使用了来自西弗吉尼亚州 2017 年和 2018 年出生的所有新生儿（N = 36,974）的基于人群的队列数据，并将分析限制在宫内物质暴露的婴儿（14%，n = 5188）。在控制母婴协变量的同时，进行多元逻辑回归分析母体糖尿病与 NAS 之间的调整关系。

结果： 

超过 28% 的糖尿病女性的婴儿患有 NAS，而 34.8% 的非糖尿病女性的婴儿患有 NAS。在控制协变量后，与非糖尿病母亲所生的婴儿相比，糖尿病女性所生的婴儿发生 NAS 的调整优势比为 0.70（95% 置信区间：0.51, 0.94）。与我们的假设相反，该研究表明孕期母体糖尿病与婴儿患 NAS 的风险降低有关。

对实践的影响： 

从这一假设产生的未来研究可能会对怀孕期间使用药物和糖尿病的母亲所生婴儿的实践产生潜在影响。

对研究的影响： 

应该进行更多的研究来研究葡萄糖代谢与NAS之间的关系。