Background: 

Within every neonatal clinical setting, vascular access devices are considered essential for administration of fluids, nutrition, and medications. However, use of vascular access devices is not without danger of failure. Catheter securement adhesives are being evaluated among adult populations, but to date, studies in neonatal settings are scant.

Purpose: 

This research describes the prevalence of peripherally inserted central catheter failure related to catheter securement before and after the introduction of tissue adhesive for catheter securement. The identified modifiable risks might be used to evaluate efficacy, to innovate neonatal practice and support future policy developments.

Method and Setting: 

This was a retrospective observational analysis of routinely collected anonymized intravenous therapy-related data. The study was carried out at the tertiary neonatal intensive care unit (112 beds) of the Women's Wellness and Research Center of Hamad Medical Corporation, Doha, Qatar.

Results: 

The results showed that the use of an approved medical grade adhesive for catheter securement resulted in significantly less therapy failures, compared with the control group. This remains significant after adjusting for day of insertion, gestational age, birth weight, and catheter type.

Implications for Practice and Research: 

In parallel with currently published international literature, this study's findings support catheter securement with an octyl-based tissue adhesive in use with central venous catheters. When device stabilization is most pertinent, securement with tissue adhesive is a safe and effective method for long-term vascular access among the neonatal population.

中文翻译：

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新生儿 PICC 使用中的氰基丙烯酸酯固定：一项为期 4 年的观察性研究

背景： 

在每个新生儿临床环境中，血管通路装置被认为对于液体、营养和药物的管理是必不可少的。然而，使用血管通路装置并非没有失败的危险。正在成人人群中评估导管固定粘合剂，但迄今为止，在新生儿环境中的研究很少。

目的： 

这项研究描述了在引入组织粘合剂用于导管固定之前和之后与导管固定相关的外周插入中心导管失败的普遍性。已确定的可修改风险可用于评估疗效、创新新生儿实践并支持未来的政策发展。

方法和设置： 

这是对常规收集的匿名静脉治疗相关数据的回顾性观察分析。该研究是在卡塔尔多哈哈马德医疗公司妇女健康和研究中心的三级新生儿重症监护室（112 个床位）进行的。

结果： 

结果表明，与对照组相比，使用经批准的医用级粘合剂固定导管可显着减少治疗失败。在调整插入天数、胎龄、出生体重和导管类型后，这仍然很重要。

对实践和研究的启示： 

与目前发表的国际文献同时，本研究的结果支持在中心静脉导管中使用辛基组织粘合剂固定导管。当装置稳定性最重要时，用组织粘合剂固定是新生儿人群中长期血管通路的一种安全有效的方法。