Nitric-Oxide-Releasing aza-BODIPY: A New Near-Infrared J-Aggregate with Multiple Antibacterial Modalities,Angewandte Chemie International Edition

当前位置： X-MOL 学术 › Angew. Chem. Int. Ed. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Nitric-Oxide-Releasing aza-BODIPY: A New Near-Infrared J-Aggregate with Multiple Antibacterial Modalities
Angewandte Chemie International Edition ( IF 16.1 ) Pub Date : 2022-06-03 , DOI: 10.1002/anie.202207250
Xinyao Bao ₁ , Shaoqiu Zheng ₁ , Lei Zhang ₁ , Aizong Shen ₁ , Guoying Zhang ₁ , Shiyong Liu ₁ , Jinming Hu ₁

Affiliation

The covalent attachment of nitric oxide (NO)-releasing N-nitrosamine moieties to aza-BODIPY derivatives affords the first NO-releasing NIR J-aggregate of BDP-NO. The delicate modulation of the aggregation states of BDP-NO enables different antibacterial modalities, and the combination of NO release and photothermal therapy (PTT) can synergistically treat MRSA infections while attenuating PTT-associated inflammatory responses.

中文翻译：

一氧化氮释放氮杂-BODIPY：一种具有多种抗菌方式的新型近红外J-聚集体

释放一氧化氮 (NO) 的N-亚硝胺部分与氮杂-BODIPY 衍生物的共价连接提供了BDP-NO的第一个释放 NO 的 NIR J-聚集体。BDP-NO聚集状态的精细调节能够实现不同的抗菌方式，NO 释放和光热疗法 (PTT) 的结合可以协同治疗 MRSA 感染，同时减轻 PTT 相关的炎症反应。

更新日期：2022-06-03

点击分享查看原文

点击收藏

阅读更多本刊最新论文本刊介绍/投稿指南11