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Nitric-Oxide-Releasing aza-BODIPY: A New Near-Infrared J-Aggregate with Multiple Antibacterial Modalities
Angewandte Chemie International Edition ( IF 16.1 ) Pub Date : 2022-06-03 , DOI: 10.1002/anie.202207250
Xinyao Bao 1 , Shaoqiu Zheng 1 , Lei Zhang 1 , Aizong Shen 1 , Guoying Zhang 1 , Shiyong Liu 1 , Jinming Hu 1
Affiliation  

The covalent attachment of nitric oxide (NO)-releasing N-nitrosamine moieties to aza-BODIPY derivatives affords the first NO-releasing NIR J-aggregate of BDP-NO. The delicate modulation of the aggregation states of BDP-NO enables different antibacterial modalities, and the combination of NO release and photothermal therapy (PTT) can synergistically treat MRSA infections while attenuating PTT-associated inflammatory responses.

中文翻译:

一氧化氮释放氮杂-BODIPY:一种具有多种抗菌方式的新型近红外J-聚集体

释放一氧化氮 (NO) 的N-亚硝胺部分与氮杂-BODIPY 衍生物的共价连接提供了BDP-NO的第一个释放 NO 的 NIR J-聚集体。BDP-NO聚集状态的精细调节能够实现不同的抗菌方式,NO 释放和光热疗法 (PTT) 的结合可以协同治疗 MRSA 感染,同时减轻 PTT 相关的炎症反应。
更新日期:2022-06-03
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