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Multicellular dynamics of zonal liver regeneration mapped in space and time
Cell Stem Cell ( IF 19.8 ) Pub Date : 2022-06-02 , DOI: 10.1016/j.stem.2022.05.008
Feng Chen 1 , Jan S Tchorz 2
Affiliation  

In this issue, Ben-Moshe et al. (2022) use spatiotemporally resolved single-cell and spatial transcriptomic profiling to dissect the multicellular dynamics enabling zonal liver regeneration. They highlight how pan-zonal compensatory hepatocyte proliferation, transient reprogramming of peri-injury hepatocytes, and concerted zonated action of different liver cell types orchestrate the healing process.



中文翻译:

在空间和时间上映射的带状肝再生的多细胞动力学

在这个问题上,Ben-Moshe 等人。(2022 年)使用时空分辨的单细胞和空间转录组分析来剖析多细胞动力学,从而实现带状肝再生。他们强调了泛区代偿性肝细胞增殖、损伤周围肝细胞的瞬时重编程以及不同肝细胞类型的协同分区作用如何协调愈合过程。

更新日期:2022-06-03
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