Nanoparticles have been largely designed and exploited for intracellular delivery of biomacromolecules, classically via endocytosis pathways. A recent work published by Miserez et al. in Nature Chemistry showed that micron-sized liquid droplets can be used for efficient and cytosolic delivery of cargoes including proteins, peptides, and mRNAs, opening new avenues for intracellular delivery of macromolecular therapeutics.

中文翻译：

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大尺寸但已准备好进入：用于多种细胞内递送的微米级液滴

纳米颗粒主要被设计和开发用于生物大分子的细胞内递送，通常通过内吞作用途径。Miserez 等人最近发表的一项工作。自然化学中的一项研究表明，微米级液滴可用于有效和细胞溶质递送包括蛋白质、肽和 mRNA 在内的货物，为大分子治疗药物的细胞内递送开辟了新途径。