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Organocatalyzed Cross-Nucleophile Couplings: Umpolung of Catalytic Enamines
Accounts of Chemical Research ( IF 16.4 ) Pub Date : 2022-06-02 , DOI: 10.1021/acs.accounts.2c00149 Nomaan M Rezayee 1 , Johannes N Lamhauge 1 , Karl Anker Jørgensen 1
Accounts of Chemical Research ( IF 16.4 ) Pub Date : 2022-06-02 , DOI: 10.1021/acs.accounts.2c00149 Nomaan M Rezayee 1 , Johannes N Lamhauge 1 , Karl Anker Jørgensen 1
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The concept of umpolung, or polarity reversal, introduced by Seebach and Corey nearly half a century ago, ushered a new paradigm into synthetic chemistry. Novel connections were able to be forged among functional groups that were typically inaccessible. Conceptually, an umpolung reaction is identified only upon retrosynthetic analysis. Stoichiometric examples have served as a platform to develop and refine elegant methodologies into catalytic processes. The advent of these unconventional arrangements of canonical synthons into new points of diversity has expanded the repertoire of the synthetic toolbox. Within this context, asymmetric organocatalyzed methodologies remain rare, and there are even fewer aminocatalyzed variants.
中文翻译：
有机催化的交叉亲核偶联：催化烯胺的 Umpolung
近半个世纪前由 Seebach 和 Corey 引入的 umpolung 或极性反转的概念为合成化学开辟了新的范式。能够在通常无法访问的功能组之间建立新的连接。从概念上讲，只有在逆合成分析时才能确定 umpolung 反应。化学计量示例已作为一个平台，将优雅的方法开发和改进为催化过程。规范合成器的这些非常规排列进入新的多样性点的出现扩展了合成工具箱的曲目。在这种情况下，不对称有机催化方法仍然很少见，氨基催化的变体更少。
更新日期：2022-06-02
中文翻译：
有机催化的交叉亲核偶联：催化烯胺的 Umpolung
近半个世纪前由 Seebach 和 Corey 引入的 umpolung 或极性反转的概念为合成化学开辟了新的范式。能够在通常无法访问的功能组之间建立新的连接。从概念上讲，只有在逆合成分析时才能确定 umpolung 反应。化学计量示例已作为一个平台，将优雅的方法开发和改进为催化过程。规范合成器的这些非常规排列进入新的多样性点的出现扩展了合成工具箱的曲目。在这种情况下，不对称有机催化方法仍然很少见，氨基催化的变体更少。
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