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Umpolung AlaB Reagents for the Synthesis of Non-Proteogenic Amino Acids, Peptides and Proteins**
Angewandte Chemie International Edition ( IF 16.1 ) Pub Date : 2022-06-02 , DOI: 10.1002/anie.202207153
Feng Zhu 1 , Eric Miller 2 , Wyatt C Powell 2 , Kelly Johnson 2 , Alexander Beggs 2 , Garrett E Evenson 2 , Maciej A Walczak 2
Affiliation  

A novel amino acid synthon in the form of boronoalanine (AlaB) suitable for umpolung peptide/protein functionalization is described. It is demonstrated that AlaB can be incorporated into peptides and proteins, and remains stable under solid-phase synthesis, native chemical ligation, and radical desulfurization. Furthermore, AlaB is a competent partner in inter(intra)molecular C(sp3)−C(sp2) cross-couplings.

中文翻译:

用于合成非蛋白氨基酸、肽和蛋白质的 Umpolung AlaB 试剂**

描述了一种适用于 umpolung 肽/蛋白质功能化的硼丙氨酸 (Ala B )形式的新型氨基酸合成子。结果表明,Ala B可以掺入肽和蛋白质中,并且在固相合成、天然化学连接和自由基脱硫下保持稳定。此外,Ala B是分子间(内)C( sp 3 )−C( sp 2 ) 交叉偶联的有效伙伴。
更新日期:2022-06-02
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