A DNA-based strategy is developed for spatially-selective amplification of acidic signals in the extracellular milieu of tumors. Amplified imaging of the tumor microenvironment with improved sensitivity was achieved by acidity-responsive engineering of the cell surface with DNA receptors for controlled recruitment of fluorescent amplifiers.

中文翻译：

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通过 DNA 放大器的空间选择性募集在肿瘤微环境中进行轻度酸中毒定向信号放大

开发了一种基于 DNA 的策略，用于肿瘤细胞外环境中酸性信号的空间选择性放大。通过用 DNA 受体对细胞表面进行酸度响应工程以控制荧光放大器的募集，实现了具有更高灵敏度的肿瘤微环境的放大成像。