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Effects of bamboo leaf extract intervention on the growth performance, antioxidant capacity, and hepatic apoptosis in suckling piglets
Journal of Animal Science ( IF 2.7 ) Pub Date : 2022-06-01 , DOI: 10.1093/jas/skac201
Ge Yu 1 , Shuli Ji 1 , Yang Yun 1 , Kang Cheng 1 , Hao Zhang 1 , Peilu Jia 1 , Tian Wang 1 , Lili Zhang 1
Affiliation  

This study investigated whether bamboo leaf extract (BLE) could improve the growth performance, antioxidant capacity, and inhibit hepatic apoptosis in suckling piglets. Sixty-four suckling piglets were orally gavaged with vehicle (CON group) or 100, 200, or 300 mg BLE/kg body weight (BL, BM, and BH groups) at 3 days of age for 21 days (n = 8). The results showed that BLE treatment had no effects on the growth performance (P > 0.05). Compared with the CON group, the BM and BH groups decreased (P <0.05) the jejunal and hepatic malondialdehyde (MDA) contents. Supplementation with BLE increased antioxidant enzymes activities and the expressions of nuclear factor erythroid 2-related factor 2 (Nrf2) and several targeted genes in the jejunum and liver of suckling piglets. The hepatic apoptosis rate was lower (P >0.05) in BLE treatment than in the CON group. Compared with the CON group, the BLE groups showed increased (P <0.05) mRNA levels of B-cell-lymphoma protein 2 (BCL-2), while decreased (P <0.05) BCL-2-associated X (BAX) and cysteine aspartate specific protease-3 (caspase-3) mRNA levels. The results of protein expressions of BCL-2 and caspase-3 were consistent with those of mRNA levels. Altogether, our results indicated that BLE intervention can improve the antioxidant capacity and inhibit hepatic apoptosis in suckling piglets.

中文翻译:

竹叶提取物干预对乳猪生长性能、抗氧化能力和肝细胞凋亡的影响

本研究调查了竹叶提取物 (BLE) 是否可以改善哺乳仔猪的生长性能、抗氧化能力和抑制肝细胞凋亡。64 头哺乳仔猪在 3 日龄时用载体(CON 组)或 100、200 或 300 mg BLE/kg 体重(BL、BM 和 BH 组)口服管饲 21 天(n = 8)。结果表明,BLE处理对生长性能没有影响(P>0.05)。与CON组相比,BM组和BH组的空肠和肝丙二醛(MDA)含量降低(P<0.05)。补充 BLE 可增加乳猪空肠和肝脏中的抗氧化酶活性和核因子红细胞 2 相关因子 2 (Nrf2) 和几个靶向基因的表达。肝细胞凋亡率较低(P>0. 05) BLE 治疗组优于 CON 组。与CON组相比,BLE组B细胞淋巴瘤蛋白2(BCL-2)的mRNA水平升高(P <0.05),而BCL-2相关X(BAX)降低(P <0.05)和半胱氨酸天冬氨酸特异性蛋白酶 3 (caspase-3) mRNA 水平。BCL-2、caspase-3蛋白表达结果与mRNA水平一致。总之,我们的研究结果表明,BLE干预可以提高乳猪的抗氧化能力并抑制肝细胞凋亡。BCL-2、caspase-3蛋白表达结果与mRNA水平一致。总之,我们的研究结果表明,BLE干预可以提高乳猪的抗氧化能力并抑制肝细胞凋亡。BCL-2、caspase-3蛋白表达结果与mRNA水平一致。总之,我们的研究结果表明,BLE干预可以提高乳猪的抗氧化能力并抑制肝细胞凋亡。
更新日期:2022-06-01
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