Centenarians exhibit extreme longevity and compression of morbidity and display a unique genetic signature. Centenarians’ offspring seem to inherit centenarians’ compression of morbidity, as measured by lower rates of age-related pathologies. We aimed to ascertain whether centenarians’ offspring are less frail and whether they are endowed with a “centenarian genetic footprint” in a case-control study, matched 1:1 for gender, age ±5 years, and place of birth and residence. Cases must have a living parent aged 97 years or older, aged 65-80 years, community-dwelling, not suffering from a terminal illness, or less than 6 months of life expectancy. Controls had to meet the same criteria as cases except for the age of death of their parents (not older than 89 years). Centenarians were individuals 97 years or older. Frailty phenotype was determined by Fried’s Criteria. We collected plasma and peripheral blood mononuclear cells from 63 centenarians, 88 centenarians’ offspring, and 88 non-centenarians’ offspring. miRNA expression and mRNA profiles were performed by the GeneChip miRNA 4.0 Array (Thermo Fisher Scientific) and GeneChip Clariom S Human Array (Thermo Fisher Scientific), respectively. We found a lower incidence of frailty among centenarians’ offspring when compared to their contemporaries’ non- centenarians’ offspring (p <0.01). Both miRNA and mRNA expression patterns in centenarians’ offspring were more like those of centenarians than those of non-centenarians’ offspring (p <0.01). in conclusion, centenarians’ offspring are less frail than age-matched non-centenarians’ offspring, and this may be explained by their unique genetic endowment.

中文翻译：

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对百岁老人后代的功能转录组分析揭示了一个特定的遗传足迹，这可以解释他们比年龄匹配的非百岁老人的后代更不虚弱

百岁老人表现出极长的寿命和发病率的压缩，并显示出独特的遗传特征。百岁老人的后代似乎继承了百岁老人对发病率的压缩，这是通过与年龄相关的疾病发生率较低来衡量的。我们旨在确定百岁老人的后代是否不那么虚弱，以及他们是否在病例对照研究中具有“百岁老人遗传足迹”，性别、年龄±5 岁、出生和居住地按 1:1 匹配。病例必须有一个在世的父母年龄在 97 岁或以上、年龄在 65-80 岁、社区居住、未患绝症或预期寿命少于 6 个月。除了父母的死亡年龄（不超过 89 岁）外，对照组必须满足与病例相同的标准。百岁老人是 97 岁或以上的人。脆弱表型由 Fried 标准确定。我们收集了 63 名百岁老人、88 名百岁老人的后代和 88 名非百岁老人的后代的血浆和外周血单个核细胞。miRNA 表达和 mRNA 谱分别由 GeneChip miRNA 4.0 Array (Thermo Fisher Scientific) 和 GeneChip Clariom S Human Array (Thermo Fisher Scientific) 进行。我们发现，与同时代的非百岁老人的后代相比，百岁老人的后代虚弱的发生率较低（p <0.01）。与非百岁老人的后代相比，百岁老人后代的 miRNA 和 mRNA 表达模式更像百岁老人（p <0.01）。总而言之，百岁老人的后代比同龄非百岁老人的后代更不虚弱，