Background: Older patients with chronic renal failure (CRF) which currently is referred to as end-stage renal disease (ESRD) are associated with higher mortality. In-center nocturnal dialysis (INHD) is a new blood purification model, which is characterized by longer sessions and nighttime administration. However, no data for the efficacy of INHD in older patients with ESRD are available. This study is to analyze the effect of INHD in the treatment of older patients with ESRD.
Methods: A retrospective, observational study was conducted in a university teaching hospital. Seventy-two patients with ESRD receiving INHD were enrolled. They were divided into the older ESRD patients (age ≥ 60) group (n = 22) and the non-older ESRD patients (age < 60) group (n = 50). The causes of older ESRD patients and non-older ESRD patients receiving INHD were analyzed. Differences of laboratory test indicators of older patients with ESRD before INHD and after INHD were compared. Quality of life for older ESRD patients receiving INHD was assessed by using the Kidney Disease Quality of Life-36 Instrument (KDQOL-36).
Results: Serum concentration of hemoglobin and serum concentration of albumin of older patients with ESRD increased significantly after INHD (p < 0.05). There were similar results in the non-older cohort (p ≤ 0.05). Scores of five KDQOL-36 subscales increased significantly after INHD (p ≤ 0.001) indicated that the quality of life for old patients with ESRD was significantly improved after INHD.
Conclusion: INHD is an effective blood purification therapy that can improve the condition of renal anemia, and it may provide a potential positive impact in the malnutrition of older and non-older patients with ESRD. INHD can improve the quality of life of older patients with ESRD. The results will provide a basis for formulating new policies of blood purification therapy for older patients.



中文翻译：

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长期中心夜间血液透析可改善慢性肾功能衰竭老年患者的肾性贫血和营养不良及生活质量

背景：目前被称为终末期肾病（ESRD）的慢性肾功能衰竭（CRF）的老年患者与较高的死亡率相关。中心夜间透析（INHD）是一种新的血液净化模式，其特点是疗程更长，夜间给药。然而，尚无 INHD 对老年 ESRD 患者疗效的数据。本研究旨在分析INHD治疗老年ESRD患者的效果。
方法：在大学教学医院进行了一项回顾性观察性研究。招募了 72 名接受 INHD 的 ESRD 患者。他们被分为老年 ESRD 患者（年龄 ≥ 60）组（n = 22）和非老年 ESRD 患者（年龄 < 60）组（n = 50）。分析老年ESRD患者和非老年ESRD患者接受INHD的原因。比较老年终末期肾病患者INHD前后实验室检查指标的差异。接受 INHD 的老年 ESRD 患者的生活质量通过使用肾脏疾病生活质量 36 仪器 (KDQOL-36) 进行评估。
结果：老年 ESRD 患者 INHD 后血红蛋白浓度和血清白蛋白浓度显着升高（p< 0.05)。在非老年人群中也有类似的结果（p ≤ 0.05）。INHD 后 KDQOL-36 五个分量表的得分显着增加（p≤0.001 ）表明老年 ESRD 患者的生活质量在 INHD 后显着改善。
结论： INHD是一种有效的血液净化疗法，可以改善肾性贫血的病情，可能对老年和非老年ESRD患者的营养不良产生潜在的积极影响。INHD 可以改善老年 ESRD 患者的生活质量。研究结果将为制定老年患者血液净化治疗新政策提供依据。