Synthetic Reprogramming of Kinases Expands Cellular Activities of Proteins,Angewandte Chemie International Edition

当前位置： X-MOL 学术 › Angew. Chem. Int. Ed. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Synthetic Reprogramming of Kinases Expands Cellular Activities of Proteins
Angewandte Chemie International Edition ( IF 16.1 ) Pub Date : 2022-05-31 , DOI: 10.1002/anie.202202770
Veronika M Shoba _{1,

2} , Dhanushka N P Munkanatta Godage _{1,

2} , Santosh K Chaudhary _{1,

2} , Arghya Deb _{1,

2} , Sachini U Siriwardena _{1,

2} , Amit Choudhary _{1,

2,

3}

Affiliation

A high-yielding synthetic route to bifunctional molecules that reprogram activities of protein kinase C and engineered Abelson kinase to induce phosphorylation on neo-substrates is reported. These phosphorylations have promising inhibitory effects on the activity of Bruton's tyrosine kinase (BTK) and BCR-ABL-dependent cancer cells.

中文翻译：