Current organ preservation methods provide a narrow window (usually <12 hours) to assess, transport and implant donor grafts for human transplantation. Here we report the transplantation of a human liver discarded by all centers, which could be preserved for several days using ex situ normothermic machine perfusion. The transplanted liver exhibited normal function, with minimal reperfusion injury and the need for only a minimal immunosuppressive regimen. The patient rapidly recovered a normal quality of life without any signs of liver damage, such as rejection or injury to the bile ducts, according to a 1-year follow up. This inaugural clinical success opens new horizons in clinical research and promises an extended time window of up to 10 days for assessment of viability of donor organs as well as converting an urgent and highly demanding surgery into an elective procedure.

目前的器官保存方法提供了一个狭窄的窗口（通常小于 12 小时）来评估、运输和植入用于人体移植的供体移植物。在这里，我们报告了所有中心丢弃的人类肝脏的移植，使用非原位常温机器灌注可以将其保存数天。移植的肝脏表现出正常功能，再灌注损伤最小，只需要最小的免疫抑制方案。根据 1 年的随访，患者迅速恢复了正常的生活质量，没有任何肝损伤迹象，例如排斥反应或胆管损伤。