Personalized and point-of-care (POC) diagnoses are critical for ocular physiology and disease diagnosis. Real-time monitoring and continuous sampling abilities of tear fluid and user-friendliness have become the key characteristics for the applied ophthalmic techniques. Fluorescence technologies, as one of the most popular methods that can fulfill the requirements of clinical ophthalmic applications for optical sensing, have been raised and applied for tear sensing and diagnostic platforms in recent decades. Wearable sensors in this case have been increasingly developed for ocular diagnosis. Contact lenses, as one of the commercialized and popular tools for ocular dysfunction, have been developed as a platform for fluorescence sensing in tears diagnostics and real-time monitoring. Numbers of biochemical analytes have been examined through developed fluorescent contact lens sensors, including pH values, electrolytes, glucose, and enzymes. These sensors have been proven for monitoring ocular conditions, enhancing and detecting medical treatments, and tracking efficiency of related ophthalmic surgeries at POC settings. This review summarizes the applied ophthalmic fluorescence sensing technologies in tears for ocular diagnosis and monitoring. In addition, the cooperation of fabricated fluorescent sensor with mobile phone readout devices for diagnosing ocular diseases with specific biomarkers continuously is also discussed. Further perspectives for the developments and applications of fluorescent ocular sensing and diagnosing technologies are also provided.

中文翻译：

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用于眼科诊断的荧光传感技术

个性化和即时 (POC) 诊断对于眼部生理学和疾病诊断至关重要。泪液的实时监测和连续采样能力和用户友好性已成为应用眼科技术的关键特征。近几十年来，荧光技术作为可以满足临床眼科应用对光学传感要求的最流行的方法之一，已被提出并应用于泪液传感和诊断平台。在这种情况下，可穿戴传感器已越来越多地用于眼部诊断。隐形眼镜作为用于眼功能障碍的商业化和流行工具之一，已被开发为用于泪液诊断和实时监测中的荧光传感平台。已通过开发的荧光隐形眼镜传感器检查了许多生化分析物，包括 pH 值、电解质、葡萄糖和酶。这些传感器已被证明可用于监测眼部状况、增强和检测医学治疗，以及在 POC 环境中跟踪相关眼科手术的效率。本综述总结了泪液中应用的眼科荧光传感技术，用于眼部诊断和监测。此外，还讨论了制造荧光传感器与手机读出设备的合作，用于连续诊断具有特定生物标志物的眼部疾病。还为荧光眼部传感和诊断技术的发展和应用提供了进一步的视角。葡萄糖和酶。这些传感器已被证明可用于监测眼部状况、增强和检测医学治疗，以及在 POC 环境中跟踪相关眼科手术的效率。本综述总结了泪液中应用的眼科荧光传感技术，用于眼部诊断和监测。此外，还讨论了制造荧光传感器与手机读出设备的合作，用于连续诊断具有特定生物标志物的眼部疾病。还为荧光眼部传感和诊断技术的发展和应用提供了进一步的视角。葡萄糖和酶。这些传感器已被证明可用于监测眼部状况、增强和检测医学治疗，以及在 POC 环境中跟踪相关眼科手术的效率。本综述总结了泪液中应用的眼科荧光传感技术，用于眼部诊断和监测。此外，还讨论了制造荧光传感器与手机读出设备的合作，用于连续诊断具有特定生物标志物的眼部疾病。还为荧光眼部传感和诊断技术的发展和应用提供了进一步的视角。本综述总结了泪液中应用的眼科荧光传感技术，用于眼部诊断和监测。此外，还讨论了制造荧光传感器与手机读出设备的合作，用于连续诊断具有特定生物标志物的眼部疾病。还为荧光眼部传感和诊断技术的发展和应用提供了进一步的视角。本综述总结了泪液中应用的眼科荧光传感技术，用于眼部诊断和监测。此外，还讨论了制造荧光传感器与手机读出设备的合作，用于连续诊断具有特定生物标志物的眼部疾病。还为荧光眼部传感和诊断技术的发展和应用提供了进一步的视角。