The ketogenic diet (KD) is a high-fat and low-carbohydrate diet with controlled amounts of protein. The use of drastic caloric restriction or ultralow-carbohydrate diets increases the production of ketone bodies, which are an alternative energy substrate in situations of insufficient glucose supply. Alzheimer’s disease (AD) and Parkinson’s disease are the most common neurodegenerative diseases in the world. It is believed that carbohydrate metabolism disorders may affect the progression of these diseases, as confirmed by both animal and human studies. Among patients with AD, the presence of ketone bodies in the body can improve cerebral circulation. Among Parkinson’s patients, the presence of ketone bodies can reduce muscle tremor and stiffness, as well as improve cognitive function. The results of the research indicate that using a low-carbohydrate diet, including a KD, may have a beneficial effect on brain function in diseases that cause neuronal damage.
Dement Geriatr Cogn Disord Extra 2022;12:100–106

中文翻译：

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生酮饮食对神经退行性疾病治疗的影响及其对改善认知功能的影响

生酮饮食（KD）是一种高脂肪和低碳水化合物的饮食，蛋白质含量受控。使用严格的热量限制或超低碳水化合物饮食会增加酮体的产生，酮体是葡萄糖供应不足情况下的替代能源底物。阿尔茨海默病 (AD) 和帕金森病是世界上最常见的神经退行性疾病。正如动物和人类研究所证实的那样，据信碳水化合物代谢紊乱可能会影响这些疾病的进展。在 AD 患者中，体内酮体的存在可以改善脑循环。在帕金森病患者中，酮体的存在可以减少肌肉震颤和僵硬，并改善认知功能。
Dement Geriatr Cogn Disord Extra 2022;12:100–106