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Three-component synthesis of β-aminoxy amides
Organic Chemistry Frontiers ( IF 4.6 ) Pub Date : 2022-05-31 , DOI: 10.1039/d2qo00631f
Linwei Zeng 1 , Shuheng Xu 2 , Sunliang Cui 2 , Fengzhi Zhang 1
Affiliation  

A multicomponent reaction for the synthesis of β-aminoxy amides is described. In this reaction, N-hydroxamic acids, ynamides and aldehydes could assemble efficiently to deliver structurally diverse β-aminoxy amides under the promotion of BF3–Et2O. This protocol features readily available starting materials, high atom economy, mild reaction conditions and facile scalability. Control reactions and a crossover experiment provide insights into the process for elucidating a plausible mechanism.

中文翻译:

β-氨基氧基酰胺的三组分合成

描述了用于合成 β-氨基氧基酰胺的多组分反应。在该反应中,在BF 3 –Et 2 O 的促进下, N-异羟肟酸、炔酰胺和醛可以有效地组装以提供结构多样的β-氨基氧基酰胺。该协议具有易于获得的起始材料、高原子经济性、温和的反应条件和易于扩展。对照反应和交叉实验为阐明合理机制的过程提供了见解。
更新日期:2022-05-31
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