A simple, rapid, and sensitive method is developed for the determination of UV filters in river waters by applying the vortex-assisted dispersive liquid–liquid microextraction based on solidified floating organic droplet technique followed by the injector port silylation (IPS) in a gas chromatography-tandem mass spectrometry system. Statistical experimental design methods including general factorial design, one factor at a time, and central composite face-centered design are used for optimization purposes. Under optimized conditions, 460 µL of acetone and 30 µL of 2-dodecanone are rapidly injected into a 10 mL water sample with 10% (w/v) NaCl at pH 2.5 and vortexed for 3 min. After centrifugation, 2 µL of the separated organic solvent is subjected to auto-IPS with 1 µL of bis (trimethylsilyl) trifluoroacetamide containing 1% trimethylchlorosilane, at 260 °C for 4.5 min in programmable temperature vaporization mode. As a result of the validation studies, the intra-day and inter-day precision indicated as relative standard deviation are less than 12.4% and 18.8%, respectively. For all UV filters, detection limits are between 1.1 and 5.5 ng L⁻¹ and limit of quantitation values are between 3.1 and 16.6 ng L⁻¹. Successful recovery of extraction values (77.1%–107.4%) and good enrichment factors (231–350) are obtained.

中文翻译：

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VA-DLLME-SFOD 技术与 GC-MS/MS 联用测定地表水中的紫外线过滤剂

采用基于固化浮动有机液滴技术的涡流辅助分散液-液微萃取，然后在气相色谱中使用注射器端口甲硅烷基化 (IPS) 技术，开发了一种简单、快速、灵敏的测定河水中紫外线过滤剂的方法-串联质谱系统。统计实验设计方法包括一般因子设计、一次一个因子和中心复合面心设计用于优化目的。在优化条件下，将 460 µL 丙酮和 30 µL 2-十二酮快速注入 10 mL 含 10% (w/v) NaCl、pH 2.5 的水样中并涡旋 3 分钟。离心后，将 2 µL 分离的有机溶剂与 1 µL 含 1% 三甲基氯硅烷的双（三甲基甲硅烷基）三氟乙酰胺一起进行 auto-IPS，在可编程温度汽化模式下，在 260 °C 下持续 4.5 分钟。作为验证研究的结果，表示为相对标准偏差的日内和日间精度分别小于 12.4% 和 18.8%。对于所有 UV 过滤器，检测限在 1.1 和 5.5 ng L之间^-1和定量限在 3.1 和 16.6 ng L ^-1之间。成功恢复了提取值 (77.1%–107.4%) 和良好的富集因子 (231–350)。