With the rapid growth of the use of renal-clearable nanomedicines in disease targeting and therapy, a fundamental understanding of their injection dose responses is of great importance for future translation to clinical settings. Using glutathione-coated gold nanoparticles (GS-AuNPs) as a renal-clearable nanomedicine model for the construction of ultrasmall AuNPs with different serum protein binding abilities, we discover that the concentration-dependent serum protein binding capabilities endow GS-AuNPs with a more sensitive response to injection dose than NPs resistant to serum protein binding, resulting in greatly improved tumor-targeting efficiencies during both single and repeated low-dose injections; the performance is also distinct from nonrenal-clearable AuNPs coated with serum protein, which show decreased tumor-targeting efficiency with a decrease in the injection dose.

中文翻译：

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超小发光金纳米粒子的表面调节注射剂量响应

随着肾脏可清除纳米药物在疾病靶向和治疗中使用的快速增长，对其注射剂量反应的基本了解对于未来转化为临床环境具有重要意义。使用谷胱甘肽包覆的金纳米粒子（GS-AuNPs）作为肾脏可清除的纳米药物模型，构建具有不同血清蛋白结合能力的超小AuNPs，我们发现浓度依赖性的血清蛋白结合能力赋予GS-AuNPs更灵敏对注射剂量的反应比对血清蛋白结合有抵抗力的 NPs，在单次和重复低剂量注射期间大大提高了肿瘤靶向效率；该性能也不同于涂有血清蛋白的非肾脏可清除的 AuNP，