Detection technology for the determination of drugs, such as ketamine (KT), in sewage is of great significance in drug inspection and criminal investigation. Herein, we propose the utilization of ketamine magnetic molecularly imprinted polymers (Fe₃O₄@MIPs) as a target molecule identification and concentration container coupled with magnetic glassy carbon electrode (mGCE) for KT detection in sewage. Molecular simulations were employed to evaluate the most suitable monomer and ratio of functional monomer to template. Fe₃O₄@MIPs were prepared using microwave-assisted synthesis and possessed a “shell-core” structure with good recognition ability, superior adsorption capacity and fast kinetics toward KT. Additionally, a novel imprinted electrochemical sensor was constructed based on the magnetism of Fe₃O₄@MIPs for efficient monitoring of low concentrations of KT. The morphology and properties of Fe₃O₄@MIPs/mGCE were effectively characterized by element mapping, transmission electron microscopy, cyclic voltammetry and square wave voltammetry. KT detection was performed by square wave voltammetry within the range of 1.0 × 10⁻¹² and 4.0 × 10⁻⁴ mol L⁻¹, and the limit of detection was 8.0 × 10⁻¹³ mol L⁻¹. Furthermore, Fe₃O₄@MIPs/mGCE was successfully tested for KT determination in domestic sewage samples.

污水中氯胺酮（KT）等药物的检测技术在药品检验和刑事侦查中具有重要意义。在此，我们建议利用氯胺酮磁性分子印迹聚合物（Fe ₃ O ₄ @MIPs）作为目标分子识别和浓缩容器，结合磁性玻璃碳电极（mGCE）用于污水中的 KT 检测。分子模拟被用来评估最合适的单体和功能单体与模板的比例。铁₃ O ₄@MIPs 采用微波辅助合成制备，具有“壳核”结构，具有良好的识别能力、优异的吸附能力和对 KT 的快速动力学。此外，基于 Fe ₃ O ₄ @MIPs 的磁性构建了一种新型的印迹电化学传感器，用于有效监测低浓度的 KT。Fe ₃ O ₄ @MIPs/mGCE的形貌和性质通过元素映射、透射电子显微镜、循环伏安法和方波伏安法进行了有效表征。KT检测通过方波伏安法在1.0×10 ^-12和4.0×10 ^-4  mol L ^{-1范围内进行}，检测限为8.0×10 ^-13  mol L ^-1。此外，Fe ₃ O ₄ @MIPs/mGCE 已成功用于生活污水样品中 KT 的测定。