To date, controversies still exist regarding the exact cellular origin and regulatory mechanisms of periodontium development, which hinders efforts to achieve ideal periodontal tissue regeneration. Axin2-expressing cells in the periodontal ligament (PDL) have been shown to be a novel progenitor cell population that is essential for periodontal homeostasis. In the current study, we aimed to elucidate the regulatory role of bone morphogenetic protein receptor type 1A (BMPR1A)-mediated BMP signalling in Axin2-expressing cells during periodontium development.

中文翻译：

---

牙周膜中表达 Axin2 的细胞受骨形态发生蛋白信号传导的调节，在牙周组织发育中起关键作用

迄今为止，关于牙周组织发育的确切细胞起源和调控机制仍存在争议，这阻碍了实现理想牙周组织再生的努力。牙周韧带 (PDL) 中表达 Axin2 的细胞已被证明是一种新的祖细胞群，对牙周稳态至关重要。在目前的研究中，我们旨在阐明骨形态发生蛋白受体 1A 型（BMPR1A）介导的 BMP 信号在 Axin2 表达细胞中在牙周发育过程中的调节作用。