Ring-opening of epoxides with carboxylic acids has been widely used to prepare many high value intermediates in the polymer and pharmaceutical industries. Most of conventional processes proceeded in batch stirred reactors. As such they always suffer from low productivity and selectivity. Here we developed an advanced technology to perform the ring-opening reaction of epichlorohydrin with neodecanoic acid (NDA) for continuous production of 3-chloro-2-hydroxypropyl neodecanoate in a more efficient and safer way. A microreaction system where a microreactor connected to a stirred reactor was established. When the conversion of NDA rapidly reaching around 90% in a microreactor at 110°C, the reaction solution was transferred to a stirred reactor at 90°C. This two-stage operating mode can reduce the reaction time and improve the selectivity through free switching of temperature in the consecutive two reactors, thus substantially reducing the consumption of energy and materials.

中文翻译：

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微反应体系中环氧氯丙烷与羧酸的高效两级开环

环氧化物与羧酸的开环已广泛用于制备聚合物和制药工业中的许多高价值中间体。大多数常规工艺在间歇搅拌反应器中进行。因此，它们总是遭受低生产率和选择性的困扰。在这里，我们开发了一种先进的技术，用于执行表氯醇与新癸酸 (NDA) 的开环反应，以更高效、更安全的方式连续生产新癸酸 3-氯-2-羟丙酯。建立了微反应系统，其中微反应器连接到搅拌反应器。当 NDA 在 110°C 的微反应器中的转化率迅速达到约 90% 时，将反应溶液转移到 90°C 的搅拌反应器中。