This work investigated hydrolysed collagen (HC) powder as carrier material for particle formation via supercritical CO₂ impregnation. HC solubility and volumetric expansion in supercritical CO₂ (ρ: 605.8–834.8 g/L) were measured. Formation of HC particles loaded with lycopene dispersed in sunflower oil (LSO) (HC-LSO) using supercritical CO₂ at 100–140 bar and 40–50 °C and HC/LSO ratios of 4:1–10:1 (w/w) was studied. HC had constant solubility (0.5–0.6 g/kg CO₂) and no volumetric expansion was visibly observed. HC-LSO had similar spherical morphology, size distribution, and loading capacity (0.025 g of LSO/g of HC) between treatments. HC-LSO formed with HC/LSO ratio of 10:1 (w/w) stand out for their low agglomeration. Since HC showed low interaction with supercritical CO₂ under different conditions and preserved its powder appearance after impregnation with LSO, it is suggested to be used as carrier of lipophilic bioactive compounds in particle formation via supercritical CO₂ impregnation at moderate temperature (40–50 °C).

_{这项工作研究了水解胶原蛋白 (HC) 粉末作为通过超临界 CO 2}浸渍形成颗粒的载体材料。_{测量了超临界 CO 2} (ρ: 605.8–834.8 g/L) 中的HC 溶解度和体积膨胀。使用超临界 CO ₂在 100–140 bar 和 40–50 °C 和 HC/LSO 比为 4:1–10:1 (w/ w) 进行了研究。HC 具有恒定的溶解度 (0.5–0.6 g/kg CO ₂) 并且没有明显观察到体积膨胀。HC-LSO 在处理之间具有相似的球形形态、尺寸分布和负载能力（0.025 g LSO/g HC）。以 10:1 (w/w) 的 HC/LSO 比例形成的 HC-LSO 因其低聚集性而脱颖而出。_{由于HC在不同条件下与超临界CO 2}的相互作用较低，并且在LSO浸渍后保持其粉末外观，因此建议将其用作在中等温度（40-50°）下通过超临界CO ₂浸渍形成颗粒的亲脂性生物活性化合物的载体VS）。