Background

It has been theorized that tibialis posterior tendon dysfunction (TPTD) is a degenerative process unrelated to inflammation. The purpose of this study was to determine if inflammatory cytokines, matrix metalloproteases (MMPs), and glutamate were elevated in diseased tibialis posterior tendons (TPTs).

Methods

Matched diseased TPT, TPT insertion, and flexor digitorum longus (FDL) samples were collected from 21 patients. The samples were individually incubated in media, which was analyzed for inflammatory cytokines, MMPs, and glutamate. Histology and statistical analyses were performed.

Results

Diseased TPT and TPT insertion were significantly elevated compared to transferred FDL in eight inflammatory markers (p < 0.005). Only the diseased TPT was significantly elevated compared to the transferred FDL tendons for glutamate (p < 0.01). Histologic grading correlated with inflammatory cytokine levels.

Conclusion

Diseased TPT and TPT insertion demonstrated significantly elevated levels of inflammatory markers compared to the transferred tendons used as controls, suggesting a role for inflammation in the disease process. The amount of inflammation correlated with increased tendon degradation.

Level of evidence

Level III

中文翻译：

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组织学分级与胫骨后肌腱功能障碍的炎症生物标志物相关

背景

据推测，胫骨后肌腱功能障碍 (TPTD) 是一种与炎症无关的退化过程。本研究的目的是确定炎症细胞因子、基质金属蛋白酶(MMP) 和谷氨酸在患病的胫骨后肌腱 (TPT) 中是否升高。

方法

从 21 名患者中收集了匹配的患病 TPT、TPT 插入和趾长屈肌 (FDL) 样本。样品分别在培养基中孵育，分析炎性细胞因子、基质金属蛋白酶和谷氨酸。进行了组织学和统计分析。

结果

与转移的 FDL 相比，患病的 TPT 和 TPT 插入在八种炎症标志物中显着升高 (p < 0.005)。与转移的谷氨酸 FDL 肌腱相比，只有患病的 TPT 显着升高 (p < 0.01)。组织学分级与炎性细胞因子水平相关。

结论

与用作对照的转移肌腱相比，患病的 TPT 和 TPT 插入显示炎症标志物水平显着升高，表明炎症在疾病过程中的作用。炎症的量与肌腱退化的增加相关。

证据等级

三级