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An Outlook Towards Nano-Sponges: A Unique Drug Delivery System and its Application in Drug Delivery
Current Drug Delivery ( IF 2.4 ) Pub Date : 2022-05-27 , DOI: 10.2174/1567201819666220520111032
Debasmita Das 1 , Tamanna Afnan 1 , Pranal Chhetri 1 , Debarupa Dutta Chakraborty 2 , Prithviraj Chakraborty 1, 2
Affiliation  

: Nanosponges are colloidal and crosslinked nanocarriers consisting of a solid mesh-like network with nanocavities to encompass various types of substances like antineoplastic, proteins, peptides, volatile oil, DNA and then incorporated into topical medications that are mainly formulated like gels, creams, lotions, ointments, liquid and powders etc., for topical drug delivery system. In the polymeric construction of nanosponges, the release of enthalpy-rich water molecules accounts for high complexation efficiency for different molecular substances. The benefits of nanosponges involve the extended and controlled release of encapsulated particles with excellent competence and great stability. Nanosponges assume a significant part to new varieties of medicaments, beautifiers, farming, horticulture, high atomic weight containing proteins, innovative fire retardants, gas transporters, and water filters. Nanosponges are a novel technology that offers controlled and targeted drug delivery by different itineraries like oral, parenteral, and topical routes. Nanosponges are an effective transporter for biologically active ingredients; therefore, it is broadly employed in anti-cancer, antiviral, antiplatelet, antilipidemic therapy. This review article gives attention to the general introduction, merits and demerits, classification, characteristic features, nanosponges development procedures, numerous factors affected by nanosponge formulation, evaluation parameters, and applications in the medicinal industry.

中文翻译:

纳米海绵展望:一种独特的药物递送系统及其在药物递送中的应用

:纳米海绵是胶体和交联的纳米载体,由带有纳米空腔的固体网状网络组成,包含各种类型的物质,如抗肿瘤、蛋白质、肽、挥发油、DNA,然后掺入主要配制为凝胶、乳膏、乳液等外用药物中、软膏、液体和粉末等,用于局部给药系统。在纳米海绵的聚合物结构中,富含焓的水分子的释放是不同分子物质高络合效率的原因。纳米海绵的好处包括延长和控制包封颗粒的释放,具有出色的性能和稳定性。纳米海绵在药物新品种、美容剂、农业、园艺、高原子量蛋白质、创新的阻燃剂、气体传输器和滤水器。纳米海绵是一种新技术,可通过口服、肠胃外和局部途径等不同路线提供受控和靶向的药物输送。纳米海绵是生物活性成分的有效转运体;因此,它被广泛应用于抗癌、抗病毒、抗血小板、降血脂治疗。这篇综述文章重点介绍了一般介绍、优点和缺点、分类、特征、纳米海绵的开发过程、受纳米海绵配方影响的众多因素、评估参数以及在医药行业的应用。肠外和局部途径。纳米海绵是生物活性成分的有效转运体;因此,它被广泛应用于抗癌、抗病毒、抗血小板、降血脂治疗。这篇综述文章重点介绍了一般介绍、优点和缺点、分类、特征、纳米海绵的开发过程、受纳米海绵配方影响的众多因素、评估参数以及在医药行业的应用。肠外和局部途径。纳米海绵是生物活性成分的有效转运体;因此,它被广泛应用于抗癌、抗病毒、抗血小板、降血脂治疗。这篇综述文章重点介绍了一般介绍、优点和缺点、分类、特征、纳米海绵的开发过程、受纳米海绵配方影响的众多因素、评估参数以及在医药行业的应用。
更新日期:2022-05-27
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