The nanoproducts prepared by electrospinning have a large specific surface area, adjustable porosity, and controllable structure. Therefore, electrospinning has attracted an increasing attention in the current drug delivery systems (CDDs). In general cognition, the morphology of electrospinning nanoproducts should be homogeneous and stable to provide reproducible functions. Thus, numerous studies have been conducted to overcome the generation of beads-on-the-string by optimizing experimental conditions. This review introduces a specific electrospun nanoproduct, which is beads-on-thestring nanofibers. The presence of beads in the beads-on-the-string nanofibers can effectively encapsulate the model drug, which reduce the initial burst release of the drug and provide sustained release. At the same time, the beads-on-the-string nanofibers with composite structures can modulate the release properties of model drugs in CDDs. This review mainly summarizes the current research on the preparation of beads-on-the-string nanofibers by electrospinning and the application of beads-on-the-string nanofibers in the field of drug delivery. The future challenges and opportunities of beads-on-the-string nanofibers are also anticipated.

中文翻译：

---

电纺串珠纳米产品：制备和药物递送应用

静电纺丝制备的纳米产品比表面积大、孔隙率可调、结构可控。因此，静电纺丝在当前的药物递送系统（CDD）中引起了越来越多的关注。在一般认知中，静电纺丝纳米产品的形态应该是均匀和稳定的，以提供可重复的功能。因此，已经进行了大量研究以通过优化实验条件来克服串珠的产生。本综述介绍了一种特定的电纺纳米产品，即串珠纳米纤维。串珠纳米纤维中珠子的存在可以有效地包裹模型药物，从而减少药物的初始突释并提供缓释。同时，具有复合结构的串珠纳米纤维可以调节 CDD 中模型药物的释放特性。本综述主要综述了静电纺丝制备串珠纳米纤维的研究现状以及串珠纳米纤维在药物递送领域的应用。还预计了串珠纳米纤维未来的挑战和机遇。