The mitochondria are a dynamic powerhouse organelle that contributes greatly to cancer therapy. Solving the current problems that occur mostly in chemotherapy and diagnosis of various cancers targeting the Mitochondria is an implying approach. In this review, it is discussed how the tethering of mitochondrial-targeting moieties to chemotherapeutics, fluorescent dyes and photothermal molecules can enhance the anticancer effect. The most extensively used mitochondrial targeting conjugate is Triphenyl phosphonium (TPP), which is a delocalized lipophilic cation that gets easily accumulated via the endocytosis mechanism due to the decreased mitochondrial membrane potential of the cancer cell. Credited for this characteristic, TPP has been extensively investigated in targeting mitochondria and delivery of Cancer theranostics. This mitochondrial targeting strategy attracted great attention in cancer targeting nanotechnology. The TPP based nanoformulation have exhibited amplified therapeutic outcomes in the treatment of various cancer. Thus, TPP is an ultimate carrier with magnificent potential as a mitochondrial targeting agent.

中文翻译：

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离域亲脂性阳离子三苯基磷：用于线粒体靶向的有希望的分子

线粒体是一种动态的强大细胞器，对癌症治疗有很大贡献。解决目前主要出现在以线粒体为靶点的各种癌症的化疗和诊断中的问题是一种隐含的方法。在这篇综述中，讨论了线粒体靶向部分与化疗药物、荧光染料和光热分子的结合如何增强抗癌效果。最广泛使用的线粒体靶向偶联物是三苯基膦 (TPP)，它是一种离域的亲脂性阳离子，由于癌细胞的线粒体膜电位降低，很容易通过内吞机制积累。由于这一特性，TPP 在靶向线粒体和癌症治疗诊断学的递送方面得到了广泛研究。这种线粒体靶向策略在癌症靶向纳米技术中引起了极大的关注。基于 TPP 的纳米制剂在治疗各种癌症方面表现出放大的治疗效果。因此，TPP 是一种终极载体，具有作为线粒体靶向剂的巨大潜力。