Synthesis of Immucillins BCX-1777 and BCX-4430 from a Common Precursor,European Journal of Organic Chemistry

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Synthesis of Immucillins BCX-1777 and BCX-4430 from a Common Precursor
European Journal of Organic Chemistry ( IF 2.5 ) Pub Date : 2022-05-27 , DOI: 10.1002/ejoc.202200428
K. A. Krishnakumar ₁ , Ravi Shankar Lankalapalli ₂

Affiliation

A standalone route for synthesis of BCX-1777 and BCX-4430: By application of an addition–reduction–cyclization synthetic strategy, an advanced intermediate was prepared from Boc-protected lactam and dihalogenated pyrrolopyrimidine, in a chemoselective and stereoselective manner. This strategy provided BCX-1777 and BCX-4430 in an improved overall yield from a common precursor.

中文翻译：

从普通前体合成免疫霉素 BCX-1777 和 BCX-4430

BCX-1777 和 BCX-4430 的独立合成路线：通过应用加成-还原-环化合成策略，以化学选择性和立体选择性的方式，由 Boc 保护的内酰胺和二卤代吡咯并嘧啶制备高级中间体。该策略为 BCX-1777 和 BCX-4430 提供了比普通前体更高的总产量。

更新日期：2022-05-27

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