Deep-Sea Discovery and Detective Work: Towards Solving the Hemicalide Structural Enigma through Computational NMR Analysis and Stereocontrolled Synthesis,European Journal of Organic Chemistry

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Deep-Sea Discovery and Detective Work: Towards Solving the Hemicalide Structural Enigma through Computational NMR Analysis and Stereocontrolled Synthesis
European Journal of Organic Chemistry ( IF 2.5 ) Pub Date : 2022-05-25 , DOI: 10.1002/ejoc.202200467
Nelson Lam ₁ , Ian Paterson ₂

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This Review highlights how the judicious and synergistic application of computational NMR analysis and stereocontrolled synthesis has enabled the incremental assignment of hemicalide-a complex and extraordinarily bioactive marine polyketide containing 21 unknown stereocentres.

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