Background Aging is the most significant risk factor of dementia. Alzheimer's disease accounts for approximately 60%-80% of all dementia cases in elderly individuals. This study aimed to examine the relationship between finger movements and brain function in patients with Alzheimer's disease, using VSRAD, and explore the relationship between VSRAD and cognitive function (MoCA-J). Methods Patients diagnosed with AD, at the Center for Comprehensive Care and Research on Memory Disorders, were included in the study. The diagnostic criteria were based on the National Institute on Aging-Alzheimer's Association. Patients were excluded based on set criteria. A finger-tapping device was used for all measurements. Participants performed the following task, in order: non-dominant hand, dominant hand, simultaneously, and alternate hands. Movements were measured for 15 s each. The relationship between distance and output was measured. MRI measurements were performed, after which VSRAD was performed using sagittal section 3D T1-weighted images. The Z-score was used to calculate the degree of atrophy. Pearson's product-moment correlation coefficient was used to analyze the relationship between the Z-score and mean values of the parameters in the finger-tapping movements. Statistical significance was set at p < 0.05. Results Sixty-two patients were included in the study. Z-scores for MoCA-J analysis, percentage of total brain atrophy in the white matter, and other VSRAD parameters showed varying negative correlations (r = -0. 28, p = 0. 035, r = -0. 31, p = 0. 020, and r = -0. 52, p < 0. 001), respectively. Varying positive correlations between Z-score and the SD of distance rate of velocity peak in extending movements in the non-dominant hand were observed. Conclusion The SD of distance rate of velocity peak in extending movements and the Z-score showed a significant relationship. An association between neuropsychological tests and overall degree of brain atrophy was also observed. Key Words: Dementia, Alzheimer's disease, VSRAD, Brain atrophy, Cognitive assessment, Mild cognitive impairment.

中文翻译：

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阿尔茨海默病手指运动特征与基于体素的特定区域分析系统的关系

背景 衰老是痴呆症最重要的危险因素。阿尔茨海默病约占老年人所有痴呆病例的 60%-80%。本研究旨在使用 VSRAD 检查阿尔茨海默病患者手指运动与脑功能之间的关系，并探讨 VSRAD 与认知功能 (MoCA-J) 之间的关系。方法 将在记忆障碍综合护理和研究中心诊断为 AD 的患者纳入研究。诊断标准基于国家老龄化研究所-阿尔茨海默氏症协会。根据设定的标准排除患者。所有测量均使用手指敲击装置。参与者按顺序执行以下任务：非惯用手、惯用手、同时和交替手。每个动作测量 15 秒。测量距离和输出之间的关系。进行 MRI 测量，之后使用矢状切面 3D T1 加权图像进行 VSRAD。Z分数用于计算萎缩程度。Pearson 的乘积矩相关系数用于分析 Z 分数与手指敲击动作中参数的平均值之间的关系。统计学显着性设定为 p < 0.05。结果 62名患者被纳入研究。MoCA-J 分析的 Z 分数、白质中总脑萎缩的百分比和其他 VSRAD 参数显示出不同的负相关（r = -0. 28, p = 0. 035, r = -0. 31, p = 0. 020, r = -0. 52, p < 0. 001)。观察到Z分数与非惯用手伸展运动中速度峰值距离率的SD之间存在不同的正相关关系。结论 伸展动作中速度峰值距离率的SD与Z-score有显着相关性。还观察到神经心理学测试与脑萎缩总体程度之间的关联。关键词：痴呆，阿尔茨海默病，VSRAD，脑萎缩，认知评估，轻度认知障碍。