Different Notch ligands have opposing roles in regulating the proliferation and differentiation of vascular smooth muscle cells in the pulmonary vasculature in pulmonary arterial hypertension. Selectively targeting Jagged 1–NOTCH3 signalling might be an effective and safe strategy for the treatment of this condition.

中文翻译：

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选择性 JAG1-NOTCH3 靶向显示治疗 PAH 的潜力

不同的 Notch 配体在调节肺动脉高压中肺血管系统中血管平滑肌细胞的增殖和分化中具有相反的作用。选择性地靶向 Jagged 1-NOTCH3 信号可能是治疗这种疾病的一种有效且安全的策略。