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Defining an exhaustion-like program that restrains autoreactive CD8+ T cells
Nature Immunology ( IF 27.7 ) Pub Date : 2022-05-27 , DOI: 10.1038/s41590-022-01211-4


Intra-islet CD8+ T cells from a mouse model of type 1 diabetes exhibit an exhausted phenotype that differs from the canonical T cell exhaustion observed in cancer and chronic viral infection. Deletion of the inhibitory receptor LAG3 in these cells accelerated diabetes incidence and partially reversed this restrained phenotype.

中文翻译:

定义一个抑制自身反应性 CD8+ T 细胞的类似衰竭的程序

来自 1 型糖尿病小鼠模型的胰岛内 CD8+ T 细胞表现出衰竭表型,这与在癌症和慢性病毒感染中观察到的典型 T 细胞衰竭不同。这些细胞中抑制性受体 LAG3 的缺失加速了糖尿病的发病率,并部分逆转了这种受限制的表型。
更新日期:2022-05-27
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