Inflammasomes function as immune-signaling platforms that assemble following pathogen detection. Direct binding of a viral protein to NLRP1 and the disruption of a previously unknown autoinhibitory NRLP1 complex drive the activation of the NLRP1 inflammasome independently of the proteasome.

中文翻译：

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病毒蛋白激活 NLRP1 炎性体

炎症小体充当免疫信号平台，在病原体检测后组装。病毒蛋白与 NLRP1 的直接结合以及先前未知的自身抑制性 NRLP1 复合物的破坏驱动了独立于蛋白酶体的 NLRP1 炎性体的激活。