Formation of N−P(O)−S Bonds from White Phosphorus via a Four-Component Reaction,Advanced Synthesis & Catalysis

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Formation of N−P(O)−S Bonds from White Phosphorus via a Four-Component Reaction
Advanced Synthesis & Catalysis ( IF 4.4 ) Pub Date : 2022-05-26 , DOI: 10.1002/adsc.202200334
Yue Zhang ₁ , Yinwei Cao ₁ , Yangyang Chi ₁ , Shuanghui Chen ₁ , Xiangzhe Zeng ₁ , Yan Liu ₂ , Guo Tang ₃ , Yufen Zhao ₄

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Functionalization of white phosphorus with disulfides, amines and KOH to phosphoramidodithioates containing both P−N, P−S and P=O bonds via a four-component reaction is presented. It proceeds with high yields and provides an attractive approach for the construction of valuable N−P(O)−S motif using a one-step strategy. The advantages of this newly developed process include a clean reaction profile, complete conversion of white phosphorus, transition metal-free and halogen-free environmentally benign system, and large-scale synthetic application. Besides, phosphoramidodithioates can also be utilized to construct P−C, P−O and P=S bonds with the appropriate reagents.

中文翻译：

白磷通过四组分反应形成 N-P(O)-S 键

介绍了通过四组分反应将白磷与二硫化物、胺和 KOH 官能化成含有 P-N、P-S 和 P=O 键的氨基二硫代磷酸酯。它以高产率进行，并为使用一步策略构建有价值的 N-P(O)-S 基序提供了一种有吸引力的方法。这种新开发的工艺的优点包括清洁的反应曲线、白磷的完全转化、无过渡金属和无卤素的环境友好系统以及大规模合成应用。此外，氨基二硫代磷酸酯也可用于与适当的试剂构建 P-C、P-O 和 P=S 键。

更新日期：2022-05-26

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