Atroposelective Construction of Nine-Membered Carbonate-Bridged Biaryls,Angewandte Chemie International Edition

当前位置： X-MOL 学术 › Angew. Chem. Int. Ed. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Atroposelective Construction of Nine-Membered Carbonate-Bridged Biaryls
Angewandte Chemie International Edition ( IF 16.1 ) Pub Date : 2022-05-27 , DOI: 10.1002/anie.202206501
Shiqi Jia ₁ , Yuhong Tian ₂ , Xin Li ₂ , Pengfei Wang ₂ , Yu Lan _{1,

3} , Hailong Yan ₂

Affiliation

An efficient method for the atroposelective construction of nine-membered carbonate-bridged biaryls was achieved through a ring-expansion process via vinylidene ortho-quinone methide (VQM) intermediates. This strategy allows the convenient construction of bridged biaryls with broad functional group tolerance under mild conditions. In bioassay studies, several agents showed considerable antiproliferative activity via the mitochondrial-related apoptosis mechanism.

中文翻译：

九元碳酸酯桥联二芳基化合物的阻转选择性构建

通过亚乙烯基邻苯醌甲基化物 (VQM) 中间体的扩环过程，实现了一种高效选择性构建九元碳酸酯桥联联芳基化合物的方法。该策略允许在温和条件下方便地构建具有广泛官能团耐受性的桥联联芳基化合物。在生物测定研究中，几种药物通过线粒体相关的细胞凋亡机制显示出相当大的抗增殖活性。

更新日期：2022-05-27

点击分享查看原文

点击收藏

阅读更多本刊最新论文本刊介绍/投稿指南11