Adipocytes-Derived Exosomal microRNA-1224 Inhibits M2 Macrophage Polarization in Obesity-Induced Adipose Tissue Inflammation via MSI2-Mediated Wnt/β-Catenin Axis,Molecular Nutrition & Food Research

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Adipocytes-Derived Exosomal microRNA-1224 Inhibits M2 Macrophage Polarization in Obesity-Induced Adipose Tissue Inflammation via MSI2-Mediated Wnt/β-Catenin Axis
Molecular Nutrition & Food Research ( IF 4.5 ) Pub Date : 2022-05-26 , DOI: 10.1002/mnfr.202100889
Dongdong Zhang ₁ , Xiaoyan Yao ₁ , Yaqin Teng ₁ , Tiantian Zhao ₁ , Liangyan Lin ₁ , Yuanyuan Li ₁ , Hongxia Shang ₁ , Yongjun Jin ₁ , Qingsong Jin ₁

Affiliation

Phenotypic switch of macrophage polarization in adipose tissue has been associated with obesity-induced adipose tissue inflammation (OATI). Therefore, this study aims to explore the possible mechanism of adipocytes-derived exosomes (ADEs) carrying microRNA-1224 (miR-1224) in M2 macrophage polarization of OATI.

中文翻译：

脂肪细胞衍生的外泌体 microRNA-1224 通过 MSI2 介导的 Wnt/β-连环蛋白轴抑制肥胖诱导的脂肪组织炎症中的 M2 巨噬细胞极化

脂肪组织中巨噬细胞极化的表型转换与肥胖引起的脂肪组织炎症（OATI）有关。因此，本研究旨在探讨脂肪细胞衍生的外泌体（ADEs）携带microRNA-1224（miR-1224）在OATI M2巨噬细胞极化中的可能机制。

更新日期：2022-05-26

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