Cyclocondensation versus Cyclocondensation Plus Dehydroxylation During the Reaction of Flavones and Hydrazine,European Journal of Organic Chemistry

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Cyclocondensation versus Cyclocondensation Plus Dehydroxylation During the Reaction of Flavones and Hydrazine
European Journal of Organic Chemistry ( IF 2.5 ) Pub Date : 2022-05-24 , DOI: 10.1002/ejoc.202200455
Carlos M. Solis ₁ , Mario O. Salazar _{1,

2} , I. Ayelen Ramallo _{1,

2} , Paula García ₁ , Ricardo L. E. Furlan _{1,

2}

Affiliation

Concomitant selective dehydroxylation during the transformation of flavones into pyrazoles with hydrazine is determined by the A-ring substitution pattern and propensity to keto–enol tautomerization. The obtained pyrazoles show varied tyrosinase inhibition properties, including one nanomolar inhibitor.

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